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— Side-by-side comparison

Pick the right molecule.

Every figure on this page is sourced from the citation index. Toggle compounds in or out to see the comparison you actually care about. Defaults: the four most common GLP-1-family questions we get from patients.

— Compare
— Quick visualisations

The numbers, charted.

Reported weight loss at peak dose

— % body weight, 48–72 wk · phase 2/3 RCTs

Plasma half-life

— hours, supports dosing frequency

HbA1c reduction (T2D cohorts)

— %-points, baseline 7.5–8.5

GI side-effect frequency

— % reporting nausea or GI disturbance
— Patient scenarios

"Which one for…"

— Scenario 01

Maximum weight loss research

Triple-agonism wins on raw weight outcomes. Retatrutide leads the bench at 24% mean weight reduction. Tirzepatide is the runner-up with more long-term data.

— PickRetatrutide
— Scenario 02

Best evidence base

Semaglutide has the most published data: SUSTAIN, STEP, SELECT — five major program trees. The conservative pick when weight loss isn't the top priority.

— PickSemaglutide
— Scenario 03

Best tolerability profile

Tirzepatide adds GIP agonism to GLP-1, which clinically appears to dampen GI side effects relative to semaglutide at matched weight-loss levels. The pragmatic pick for sensitive patients.

— PickTirzepatide
— Scenario 04

Tendon & soft-tissue recovery research

BPC-157 has the broader mechanism portfolio. TB-500 has a more clinical-trial-driven base (TIME trial in cardiac repair). Patients often run both.

— PickBPC-157 + TB-500
— Scenario 05

Visceral fat & body comp research

Tesamorelin is a GHRH analog with FDA-approved data for visceral adipose tissue reduction — the pick when the question is fat distribution, not raw weight loss.

— PickTesamorelin
— Scenario 06

Cellular energy & longevity research

MOTS-c is a mitochondrial-derived peptide with metabolic and exercise-mimetic data. Epitalon is the long-running telomere/circadian candidate. Pair them for an NAD-style upstream program.

— PickMOTS-c + Epitalon
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Need a deeper look?

The citation index lists every paper feeding this comparison. The safety matrix gives you the side-effect profile for each.

Citation indexSafety matrixTake the matching quiz